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Most studies of the effects of aspirin on laboratory-induced pain in humans have shown no effect. A few studies showed analgesic effects. Previous work by the present authors, using indirect measures of pain intensity, showed aspirin to often increase rather than decrease the effects of a noxious stimulus. The present study, employing electric shock and 600 mg of aspirin, examined shock detection and pain thresholds, judgments of discomfort, and the maximum tolerated voltage. Aspirin had little or no effect on most subjects. In a large minority of subjects, aspirin produced a highly reliable increase in sensitivity to shock. These results can be reconciled with the clinical use of aspirin as well as with conflicting laboratory results. Methodological issues are raised concerning this domain of investigation. pain; analgesia; anxiety Submitted on December 18, 1964
Dinnerstein et al. (Wed,) studied this question.