Hypertension was associated with significantly lower scores on memory (-32%, p=0.043), clock drawing (-26%, p<0.001), and MMSE (-7.4%, p=0.02) compared to normotensive subjects.
Cross-Sectional (n=500)
Is hypertension associated with diminished cognitive function and cognitive reserve in the general population?
Higher systolic blood pressure and pulse pressure are associated with impaired cognitive function and lower cognitive reserve in the general population.
Odds Ratio: 0.94
p-value: p=0.032
OBJECTIVE: Hypertension exerts a subtle impact on the brain that is revealed by diminished cognitive function. This study aimed at evaluating the association between blood pressure components and cognitive functions and cognitive reserve. METHODS: In this cross-sectional study, 500 subjects from general population were evaluated. All neuropsychological tests were negatively associated with age; memory and executive function were also positively related with education. RESULTS: The hypertensives (HT) were less efficient than the normotensives (NT) in the test of memory with interference at 10 s (MI-10) (-32%, p = 0.043), clock drawing test (CLOX) (-26%, p < 0.001), and mini-mental state examination (MMSE) (-7.4%, p = 0.02). Lower MMSE, MI-10, and CLOX were predicted by higher systolic (OR, 0.94, p = 0.032; OR 0.96, p < 0.001; OR 0.94, p < 0.001) and higher pulse pressure (BP) (OR 0.95, p = 0.04; OR 0.97, p < 0.001; and OR 0.92, p < 0.001). The cognitive reserve index (CRI) was 8% lower in the HT (p = 0.04) and was predicted by higher pulse BP (OR 0.86, p < 0.001). The BP vectors of lower MMSE, MI-10, and CLOX were directed towards higher values of systolic and diastolic BP, that of low CRI towards higher systolic and lower diastolic. CONCLUSION: This study contributes to the belief that a link exists between BP and cognition, higher values of systolic BP being associated to impaired cognitive function.
Alipour et al. (Tue,) conducted a cross-sectional in Hypertension and Cognitive Impairment (n=500). Hypertension and higher systolic blood pressure vs. Normotension was evaluated on Lower mini-mental state examination (MMSE) score predicted by higher systolic blood pressure (OR 0.94, p=0.032). Hypertension was associated with significantly lower scores on memory (-32%, p=0.043), clock drawing (-26%, p<0.001), and MMSE (-7.4%, p=0.02) compared to normotensive subjects.