African-American women with preeclampsia/eclampsia had a significantly higher adjusted risk of inpatient maternal mortality compared to white women (adjusted OR 2.85; 95% CI 1.38-5.53).
Observational
Do African-American women with preeclampsia/eclampsia have worse maternal and fetal outcomes compared to white women?
African-American women with preeclampsia/eclampsia face significantly higher risks of inpatient maternal mortality and intrauterine fetal death compared to white women, highlighting severe racial disparities in peripartum outcomes.
Effect estimate: Adjusted OR 2.85 (95% CI 1.38-5.53)
OBJECTIVE: The mechanisms leading to worse outcomes in African-American (AA) women with preeclampsia/eclampsia remain unclear. Our objective was to identify racial differences in maternal comorbidities, peripartum characteristics, and maternal and fetal outcomes. METHODS/RESULTS: When compared to white women with preeclampsia/eclampsia, AA women had an increased unadjusted risk of inpatient maternal mortality (OR 3.70, 95% CI: 2.19-6.24). After adjustment for covariates, in-hospital mortality for AA women remained higher than that for white women (OR 2.85, 95% CI: 1.38-5.53), while the adjusted risk of death among Hispanic women did not differ from that for white women. We also found an increased risk of intrauterine fetal death (IUFD) among AA women. When compared to white women with preeclampsia, AA women had an increased unadjusted odds of IUFD (OR 2.78, 95% CI: 2.49-3.11), which remained significant after adjustment for covariates (adjusted OR 2.45, 95% CI: 2.14-2.82). In contrast, IUFD among Hispanic women did not differ from that for white women after adjusting for covariates. CONCLUSIONS AND RELEVANCE: Our data suggest that African-American women are more likely to have risk factors for preeclampsia and more likely to suffer an adverse outcome during peripartum care. Future research should examine whether controlling co-morbidities and other risk factors will help to alleviate racial disparities in outcomes in this cohort of women.
Shahul et al. (Fri,) conducted a observational in Preeclampsia/eclampsia. African-American race vs. White race was evaluated on Inpatient maternal mortality (Adjusted OR 2.85, 95% CI 1.38-5.53). African-American women with preeclampsia/eclampsia had a significantly higher adjusted risk of inpatient maternal mortality compared to white women (adjusted OR 2.85; 95% CI 1.38-5.53).