Increasing age was associated with decreased peak filling (30%) and ejection rates (20%) and increased diastolic asynchrony (from 4.7 to 6.4) despite invariable ejection fractions.
Observational (n=194)
Yes
This study establishes normal reference values for color kinesis indexes of regional left ventricular wall motion, highlighting significant age-related changes in diastolic and systolic timing despite preserved ejection fraction.
Our goal was to establish normal values for quantitative color kinesis indexes of left ventricular (LV) wall motion over a wide range of ages, which are required for objective diagnosis of regional systolic and diastolic dysfunction. Color-encoded images were obtained in 194 normal subjects (95 males, 99 females, age 2 mo to 79 yr) in four standard views. Quantitative indexes of magnitude and timing of systolic and diastolic function were studied for age- and gender-related differences. Normal limits of all ejection and filling indexes were in a narrow range (< or =25% of the mean), with no major gender-related differences. Despite invariable ejection fractions, both peak filling and ejection rates decreased with age (30 and 20%, correspondingly) with a concomitant increase in mean filling and ejection times, resulting in five- and twofold increases in the late to early filling and ejection ratios, correspondingly. Diastolic asynchrony increased with age (from 4.7 +/- 2.0 to 6.4 +/- 3.2 from the 2nd to 7th decade). The normal values of color kinesis indexes should allow objective detection of regional LV systolic and diastolic dysfunction.
Mor‐Avi et al. (Wed,) conducted a observational in Healthy subjects (n=194). Age was evaluated on Quantitative color kinesis indexes of magnitude and timing of systolic and diastolic function. Increasing age was associated with decreased peak filling (30%) and ejection rates (20%) and increased diastolic asynchrony (from 4.7 to 6.4) despite invariable ejection fractions.