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Focusing on driver-gene mutations and the pathways they control has rendered complex cancer-genome landscapes intelligible. In solid tumors of adults, alterations in as few as three driver genes appear to suffice for a cell to evolve into an advanced cancer.
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Bert Vogelstein
Kenneth W. Kinzler
New England Journal of Medicine
Johns Hopkins University
Howard Hughes Medical Institute
Sidney Kimmel Comprehensive Cancer Center
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Vogelstein et al. (Wed,) studied this question.
www.synapsesocial.com/papers/6a0cb4e4d48675e49423aa14 — DOI: https://doi.org/10.1056/nejmp1508811