Acute unilateral renal denervation in 6-week-old spontaneously hypertensive rats increased sodium and water excretion by 138% and 62%, respectively (P<0.001), unlike in Wistar-Kyoto control rats.
p-value: p=<0.001
Clearance experiments were conducted to determine the effect of acute unilateral renal denervation (DNX) on renal hemodynamics and salt and water excretion in anesthetized 6-wk-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto genetic control rats (WKY). Before DNX, SHR had higher mean arterial pressure (33%) and renal vascular resistance (RVR) (57%) and lower glomerular filtration rate (GFR) (10%); urine flow and sodium excretion were similar. Following DNX in SHR, sodium and water excretion increased by 138 and 62%, respectively (P less than 0.001); GFR and RVR were unchanged. In contrast, DNX in WKY did not affect urine flow (0%) or sodium excretion (-21%). These strain differences were observed in Okamoto-Aoki rats from two sources. Effective DNX was indicated by 95% reduction of norepinephrine content 3 days after DNX in both strains. Six-week-old Sprague-Dawley and Munich-Wistar rats, in contrast to WKY, responded to DNX with a natriuresis (+182%) and diuresis (+95%) (P less than 0.001). Renal function was unaffected by sham DNX in SHR. Our results indicate that efferent renal nerve activity has little tonic influence on the renal vasculature in these young rats. Augmented neurotransmitter release and/or tubular responsiveness may be involved in fluid and electrolyte retention and the pathogenesis of hypertension in SHR. Conversely, blunted renal neuroeffector responses may prevent WKY from developing hypertension.
Rudd et al. (Wed,) conducted a other in Hypertension. Acute unilateral renal denervation (DNX) vs. WKY rats / sham DNX was evaluated on Sodium and water excretion (p=<0.001). Acute unilateral renal denervation in 6-week-old spontaneously hypertensive rats increased sodium and water excretion by 138% and 62%, respectively (P<0.001), unlike in Wistar-Kyoto control rats.