Female sex was not associated with a difference in overall survival compared to male sex in patients with acute heart failure (HR 1.0; 95% CI 0.8-1.2; P=.981).
Cohort (n=2,609)
Does sex affect clinical features, management, and overall survival in patients with acute decompensated heart failure?
Despite significant differences in baseline clinical characteristics, etiology, and medical management upon discharge, overall survival does not differ between men and women with acute decompensated heart failure.
Hazard Ratio: 1 (95% CI 0.8–1.2)
p-value: p=.981
We assessed sex-specific differences in clinical features and outcomes of patients with acute heart failure (AHF). The Heart function Assessment Registry Trial in Saudi Arabia (HEARTS), a prospective registry, enrolled 2609 patients with AHF (34.2% women) between 2009 and 2010. Women were older and more likely to have risk factors for atherosclerosis, history of heart failure (HF), and rheumatic heart and valve disease. Ischemic heart disease was the prime cause for HF in men and women but more so in men (P < .001). Women had higher rates of hypertensive heart disease and primary valve disease (P < .001, for both comparisons). Men were more likely to have severe left ventricular systolic dysfunction. On discharge, a higher use of angiotensin-converting enzyme inhibitors, β-blockers, and aldosterone inhibitors was observed in men (P < .001 for all comparisons). Apart from higher atrial fibrillation in women and higher ventricular arrhythmias in men, no differences were observed in hospital outcomes. The overall survival did not differ between men and women (hazard ratio: 1.0, 95% confidence interval: 0.8-1.2, P = .981). Men and women with AHF differ significantly in baseline clinical characteristics and management but not in adverse outcomes.
AlFaleh et al. (Mon,) conducted a cohort in Acute heart failure (AHF) (n=2,609). Female sex vs. Male sex was evaluated on Overall survival (HR 1.0, 95% CI 0.8-1.2, p=.981). Female sex was not associated with a difference in overall survival compared to male sex in patients with acute heart failure (HR 1.0; 95% CI 0.8-1.2; P=.981).