In dogs with experimental myocardial infarction, anastomotic blood flow measured by 133Xenon clearance was initially reduced to 25% of normal but increased after the third day.
After tying the anterior descending coronary artery in dogs, solutions of 133Xenon were injected into the vessels of the infarct through a fine catheter over 10 days. The clearance of isotope, determined by an external counter, was a measure of anastomotic blood flow. Initially, mean flow was reduced to 25% of normal. After the third day, clearance rates increased, together with enlargement of interarteriolar anastomoses within the heart.
Rees et al. (Sat,) conducted a other in Experimental Myocardial Infarction. 133Xenon clearance measurement vs. Normal flow was evaluated on Anastomotic blood flow (clearance of isotope). In dogs with experimental myocardial infarction, anastomotic blood flow measured by 133Xenon clearance was initially reduced to 25% of normal but increased after the third day.