February 11, 2016Open Access
View Full PaperTricuspid regurgitation progression and regression in pulmonary arterial hypertension: implications for right ventricular and tricuspid valve apparatus geometry and patients outcome
Key Result
Tricuspid regurgitation progression in pulmonary arterial hypertension was significantly associated with all-cause mortality (log-rank P=0.0007) and adverse right ventricular remodeling.
Study Design
Type
Observational
Structured PICO
Is tricuspid regurgitation progression associated with increased mortality in patients with pulmonary arterial hypertension?
P
Population
Patients with pulmonary arterial hypertension (PAH)
O
Outcome
All-cause mortalityhard clinical
In patients with pulmonary arterial hypertension, progression of tricuspid regurgitation is associated with adverse right ventricular remodeling and increased all-cause mortality.
Main Result
p-value: p=0.0007
Abstract
AIMS: The aim of this study was to determine the mechanism of tricuspid regurgitation (TR) progression in pulmonary arterial hypertension (PAH) and its effect on survival. METHODS AND RESULTS: , P = 0.0002). TR progression was associated with all-cause mortality (log-rank P = 0.0007). CONCLUSION: In PAH, TR progression was associated with worsening pulmonary hypertension and adverse RV and TV apparatus remodelling. TR progression is associated with poor outcome in PAH.