Key result
TR progression in PAH is linked to higher mortality and adverse RV remodeling.
Why the study?
Is tricuspid regurgitation progression associated with increased mortality in patients with pulmonary arterial hypertension?
Observational
Is tricuspid regurgitation progression associated with increased mortality in patients with pulmonary arterial hypertension?
In patients with pulmonary arterial hypertension, progression of tricuspid regurgitation is associated with adverse right ventricular remodeling and increased all-cause mortality.
Answers are grounded in this paper and cite their sources.
TR progression may flag higher-risk PAH for closer monitoring; leaves open whether targeting it improves survival.
AIMS: The aim of this study was to determine the mechanism of tricuspid regurgitation (TR) progression in pulmonary arterial hypertension (PAH) and its effect on survival. METHODS AND TR progression was associated with all-cause mortality (log-rank P = 0.0007). CONCLUSION: In PAH, TR progression was associated with worsening pulmonary hypertension and adverse RV and TV apparatus remodelling. TR progression is associated with poor outcome in PAH.
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Medvedofsky et al. (2016) conducted an observational in Pulmonary arterial hypertension (PAH). Tricuspid regurgitation progression was evaluated on All-cause mortality (p=0.0007). Tricuspid regurgitation progression in pulmonary arterial hypertension was associated with all-cause mortality and adverse right ventricular remodeling.
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