Women hospitalized with a first acute coronary syndrome were significantly less likely than men to undergo diagnostic coronary angiography within 60 days (67% vs 80%; HR 0.86; 95% CI 0.84-0.89).
Cohort (n=52,565)
Yes
Does female sex reduce the likelihood of undergoing invasive diagnostic and therapeutic procedures in patients with acute coronary syndromes?
Women hospitalized with a first ACS are significantly less likely to undergo invasive diagnostic and therapeutic procedures compared to men, a disparity that persisted from 2005 to 2011.
Hazard Ratio: 0.86 (95% CI 0.84–0.89)
Absolute Event Rate: 67% vs 80%
p-value: p=<0.001
OBJECTIVES: To investigate for trends in sex-related differences in the invasive diagnostic-therapeutic cascade in a population of patients with acute coronary syndromes (ACS). DESIGN: A nationwide cohort study. SETTING: Administrative and clinical registries covering all hospitalisations, invasive cardiac procedures and deaths in the Danish population of 5.6 million inhabitants. PARTICIPANTS: We included 52,565 patients aged 30-90 years who were hospitalised with a first ACS from January 2005 to November 2011. Follow-up was 60 days from the day of index admission. MAIN OUTCOME MEASURES: Diagnostic coronary angiography, percutaneous coronary intervention or coronary artery bypass within 60 days of index admission. RESULTS: Women constituted 36%, were older, had more comorbidity and were less likely to be admitted to a hospital with cardiac catheterisation facilities than men. Mortality rates were similar for both sexes. Diagnostic coronary angiography was performed less frequently on women compared with men, both within 1 day (31% vs 42%; p0.05). CONCLUSIONS: In this nationwide study, men were more likely to undergo an invasive approach than women when hospitalised with a first ACS--a difference persisting from 2005 to 2011. Future studies should focus on the potential mechanisms behind this differential treatment.
Hansen et al. (Mon,) conducted a cohort in Acute coronary syndromes (n=52,565). Female sex vs. Male sex was evaluated on Diagnostic coronary angiography within 60 days of index admission (HR 0.86, 95% CI 0.84-0.89, p=<0.001). Women hospitalized with a first acute coronary syndrome were significantly less likely than men to undergo diagnostic coronary angiography within 60 days (67% vs 80%; HR 0.86; 95% CI 0.84-0.89).