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This Perspective describes general methods for the preparation of polyfunctional zinc organometallics and their use in Negishi cross-coupling reactions. Recent advances including new ligands and palladium catalysts are described. Related Negishi cross-coupling reactions involving Ni-, Cu-, Co-, and Fe-catalyzed cross-couplings are covered. The availability of a range of zinc organometallics combined with new efficient catalysts allows for efficient cross-coupling reactions with various organic electrophiles under usually mild conditions.
Haas et al. (Wed,) studied this question.