December 31, 1957
Hemodynamic Determinants of Oxygen Consumption of the Heart With Special Reference to the Tension-Time Index
Key Points
- The aim is to identify the hemodynamic factors affecting oxygen consumption in the heart.
- Utilized isolated, metabolically supported, nonfailing canine hearts.
- Assessed the total tension developed by the myocardium.
- Evaluated the significance of the Tension-Time Index.
- The total tension developed by the myocardium was identified as the primary determinant of oxygen utilization.
- Findings emphasize the relevance of Laplace's law in understanding heart efficiency.
- Implications shed light on the low efficiency of the failing heart.
Abstract
The hemodynamic determinants of myocardial oxygen utilization were ascertained in the isolated, metabolically supported, nonfailing canine heart. The primary determinant was found to be the total tension developed by the myocardium as indicated by the area beneath the systolic pressure curve (Tension-Time Index). The significance of these findings for the understanding of the low efficiency of the failing heart and the consequently increased importance of Laplace's law are discussed.
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Authors
S
Stanley J. Sarnoff
Washington University in St. Louis
Eugene Braunwald
Boston University
G
G. H. Welch
Western Infirmary
Journals
American Journal of Physiology-Legacy Content
Actions
Institutions
National Heart Lung and Blood Institute
References and Citations
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