An Investigation of Report Bias in a Case-Control Study of Pregnancy Outcome

Mackenzie, S. G., and A. Lfppman (Dept of Epidemiology and Biostatistics, McGill U., Montreal, Quebec H3A 1A2, Canada). An investigation of report bias in a case-control study of pregnancy outcome. Am J Epidemiol 1989;129:65–75. The role of report (recall) bias In case-control studies of possible reproductive hazards was Investigated In a study of women who gave birth at the Royal Victoria Hospital, Montreal from September 1983 to May 1985. Women were questioned twice (early In pregnancy after delivery) about exposures that might influence pregnancy outcome. The two sets of responses of case mothers, control mothers, and mothers of Infants of Intermediate health status were then compared. Similar inconsistencies in the reporting of 39 exposure variables were common In all three groups, with postdelivery deletion of previous reports more frequent than addition of new Information. Changes In reporting were not associated with pregnancy outcome, maternal concern about the baby or maternal soclodemographic characteristics. Odds ratios of exposure estimated from the two sets of data did not differ importantly. Moreover, there was no postdellvery trend to Increases, or decreases, In the estimates of the odds ratios. The data do not provide evidence of biased reporting of exposures.