Wild-type transthyretin cardiac amyloidosis is highlighted as a potentially modifiable cause of heart failure with preserved ejection fraction that can be diagnosed using technetium 99m bone tracers.
Highlights the importance of screening for wild-type transthyretin cardiac amyloidosis using technetium 99m bone tracers as a potentially modifiable cause of HFpEF.
This editorial refers to ‘Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction’, by F. Gonzalez-Lopez et al ., on page doi:10.1093/eurheartj/ehv338. Heart failure with a normal or preserved ejection fraction (HFnEF/HFpEF) is a heterogeneous clinical syndrome without proven treatments. Numerous biological mechanisms have been implicated in the genesis of HFnEF/HFpEF and include intrinsic cardiomyocyte stiffness related to abnormal calcium homeostasis, and cytoskeletal and extracellular matrix (ECM) abnormalities. Given the lack of efficacy of pharmacological therapies, there is a growing emphasis on how co-morbidities influence the development of this clinical syndrome,1 with an emerging hypothesis that co-morbidities drive its phenotypic expression.2 Characterization of HFnEF/HFpEF stratified by aetiological subgroups may therefore identify relevant cohorts for investigation and treatable pathophysiological mechanisms.3 Figure 1 Screening and treatment paradigm for unveiling transthyretin amyloid (ATTR) as a potentially modifiable cause of heart failure with preserved ejection fraction (HFpEF). The diagnosis of TTR cardiac amyloidosis among patients hospitalized with heart failure ( A ) can be ascertained using technetium 99 m bone tracers ( B ) so that emerging therapies may …
Castaño et al. (Tue,) conducted a editorial in Heart failure with preserved ejection fraction (HFpEF) and wild-type transthyretin cardiac amyloidosis. Wild-type transthyretin cardiac amyloidosis is highlighted as a potentially modifiable cause of heart failure with preserved ejection fraction that can be diagnosed using technetium 99m bone tracers.