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February 26, 2016Open Access

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart Failure

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Key points are not available for this paper at this time.

Abstract

Mitochondrial autophagy is transiently activated and then downregulated in the mouse heart in response to pressure overload. Downregulation of mitochondrial autophagy plays an important role in mediating the development of mitochondrial dysfunction and heart failure, whereas restoration of mitochondrial autophagy attenuates dysfunction in the heart during pressure overload.

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Authors

Akihiro Shirakabe

Heart Failure & Transplant

Peiyong Zhai

Heart Failure & Transplant

Yoshiyuki Ikeda

Kagoshima University

Journals

The Journal of Physiological Sciences

Circulation

Actions

Institutions

Kyushu University

National Yang Ming Chiao Tung University

Taipei Veterans General Hospital

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Shirakabe et al. (Fri,) studied this question.

synapsesocial.com/papers/69df142ad9e0feb21c591722 — DOI: https://doi.org/10.1161/circulationaha.115.020502

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Identification of a candidate therapeutic autophagy-inducing peptide· 2013 · 759 citations
Discovery of Atg5/Atg7-independent alternative macroautophagy· 2009 · 1,093 citations
Mechanisms of mitophagy· 2010 · 3,201 citations
Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion· 2007 · 1,483 citations
Autophagy Plays an Essential Role in Mediating Regression of Hypertrophy during Unloading of the Heart· 2013 · 93 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Identification of a candidate therapeutic autophagy-inducing peptide· 2013 · 759 citations
Discovery of Atg5/Atg7-independent alternative macroautophagy· 2009 · 1,093 citations
Mechanisms of mitophagy· 2010 · 3,201 citations
Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion· 2007 · 1,483 citations
Autophagy Plays an Essential Role in Mediating Regression of Hypertrophy during Unloading of the Heart· 2013 · 93 citations

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart Failure

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider