Does 90 cc of whisky containing 43% alcohol alter hemodynamics in nonalcoholics with cardiac disorders?
In nonalcoholics with cardiac disorders, acute ingestion of whisky significantly increases left ventricular end-diastolic pressure and peripheral resistance, challenging the view that alcohol acts as a peripheral vasodilator.
After 30 minutes, 90 cc of whisky containing 43% alcohol produced no significant changes in heart rate, systemic arterial pressure or pulmonary artery pressure in 15 nonalcoholics with cardiac disorders. Left ventricular end-diastolic pressure rose significantly. The stroke index remained the same or fell while arterial pressure did not change, consequently peripheral resistance rose, contrary to the view that alcohol is a peripheral vasodilator.
Gould et al. (Fri,) studied this question.
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