The combination of high systolic blood pressure and depression was associated with an 83% higher adjusted risk of MACE compared with reference systolic blood pressure without depression.
Cohort (n=35,537)
Does the combination of high systolic blood pressure and depression increase the risk of major adverse cardiovascular events in patients with cardiometabolic disease?
The combination of high systolic blood pressure and depression synergistically increases the risk of major adverse cardiovascular events in patients with cardiometabolic disease, highlighting the need for closer monitoring.
Hazard Ratio: 1.83
The authors studied the joint effect of blood pressure (BP) and depression on the risk of major adverse cardiovascular outcome in patients with existing cardiometabolic disease. A cohort of 35,537 patients with coronary heart disease, diabetes, or stroke underwent depression screening and BP measurement recorded concurrently. The authors used Cox's proportional hazards to calculate risk of major adverse cardiovascular event (MACE; myocardial infarction/heart failure/stroke or cardiovascular death) over 4 years associated with baseline BP and depression. A total of 11% (3939) had experienced a MACE within 4 years. Patients with very high systolic BP (160-240 mm Hg; hazard ratio, 1.28) and depression (hazard ratio, 1.22) at baseline had significantly higher adjusted risk. Depression had a significant interaction with systolic BP in risk prediction (P=.03). Patients with a combination of high systolic BP and depression at baseline had 83% higher adjusted risk of MACE, as compared with patients with reference systolic BP without depression. Patients with cardiometabolic disease and comorbid depression may benefit from closer monitoring of systolic BP.
Jani et al. (Sun,) conducted a cohort in Cardiometabolic disease (n=35,537). Combination of high systolic blood pressure and depression vs. Reference systolic blood pressure without depression was evaluated on Major adverse cardiovascular event (MACE; myocardial infarction/heart failure/stroke or cardiovascular death) (HR 1.83). The combination of high systolic blood pressure and depression was associated with an 83% higher adjusted risk of MACE compared with reference systolic blood pressure without depression.