Pre-admission use of β-blockers (RR 0.542; 95% CI 0.357-0.824) and ACE inhibitors (RR 0.710; 95% CI 0.512-0.986) was associated with reduced hospital mortality in patients with acute myocardial infarction.
Observational (n=1,133)
No
Does pharmacotherapy preceding AMI reduce hospital mortality in patients admitted with acute myocardial infarction?
Prior use of beta-blockers and ACE inhibitors is associated with reduced hospital mortality in patients admitted with acute myocardial infarction, yet these medications are significantly underutilized.
Effect estimate: RR 0.542 (95% CI 0.357-0.824)
Aim. To assess the patients’ pharmacotherapy preceding the acute myocardial infarction (AMI) and to assess the effects of this therapy on hospital mortality. Material and methods. 1133 patients were enrolled into the LIS AMI register . All these patients experienced AMI leading to hospital admitting in the territory of one of the districts of the Moscow Region during 3 years. The pharmacotherapy that patients received before AMI was analyzed as well as the influence of different drugs on the hospital mortality risk. Results. 172 of 1133 patients (15.2%) died in hospital. Before admission 21.4% of patients received β-blockers, 35.3% — ACE inhibitors, 15.7% — antiplatelet drugs, 1.9% — statins. Reduction in the hospital mortality rate was shown for β-blockers relative risk (RR)=0.542, confidence interval (CI) =0.357–0.824 and ACE inhibitors (RR=0.710, CI=0.512–0.986). Conclusion. A significant part of patients with high risk of AMI does not receive drugs with proven positive effect on the life prognosis.
Marcevich et al. (Sun,) conducted a observational in Acute myocardial infarction (n=1,133). Pharmacotherapy before AMI (β-blockers, ACE inhibitors) vs. No prior pharmacotherapy was evaluated on Hospital mortality (RR 0.542, 95% CI 0.357-0.824). Pre-admission use of β-blockers (RR 0.542; 95% CI 0.357-0.824) and ACE inhibitors (RR 0.710; 95% CI 0.512-0.986) was associated with reduced hospital mortality in patients with acute myocardial infarction.