Heart failure with left ventricular dilatation is associated with a loss of optimized vortex-wall interaction, with the vortex ring filling only 35% of the ventricle at end-diastole compared to 53% in healthy controls.
Cross-Sectional (n=39)
No
Does vortex ring behavior and its coupling with left ventricular volume differ between healthy controls and heart failure patients?
Healthy hearts demonstrate a strong coupling between vortex ring and cardiac volumes, an optimized phenotype that is lost in heart failure, suggesting vortex ring dynamics as a potential marker of cardiac health.
Absolute Event Rate: 35% vs 53%
The laws of fluid dynamics govern vortex ring formation and precede cardiac development by billions of years, suggesting that diastolic vortex ring formation is instrumental in defining the shape of the heart. Using novel and validated magnetic resonance imaging measurements, we show that the healthy left ventricle moves in tandem with the expanding vortex ring, indicating that cardiac form and function is epigenetically optimized to accommodate vortex ring formation for volume pumping. Healthy hearts demonstrate a strong coupling between vortex and cardiac volumes (R(2) = 0.83), but this optimized phenotype is lost in heart failure, suggesting restoration of normal vortex ring dynamics as a new, and possibly important consideration for individualized heart failure treatment. Vortex ring volume was unrelated to early rapid filling (E-wave) velocity in patients and controls. Characteristics of vortex-wall interaction provide unique physiologic and mechanistic information about cardiac diastolic function that may be applied to guide the design and implantation of prosthetic valves, and have potential clinical utility as therapeutic targets for tailored medicine or measures of cardiac health.
Arvidsson et al. (Fri,) conducted a cross-sectional in Heart failure with pathological left ventricular dilatation (n=39). Heart failure with left ventricular dilatation vs. Healthy controls was evaluated on Vortex ring volume as a percentage of total left ventricular volume at end-diastole. Heart failure with left ventricular dilatation is associated with a loss of optimized vortex-wall interaction, with the vortex ring filling only 35% of the ventricle at end-diastole compared to 53% in healthy controls.