Bilateral renal denervation prevented the development of stress-induced hypertension in borderline hypertensive rats when performed after 5 weeks of stress, but not after 11 weeks.
Does bilateral renal denervation prevent the development of stress-induced hypertension in borderline hypertensive rats?
Bilateral renal denervation prevents the development of stress-induced hypertension in borderline hypertensive rats if performed early, suggesting a critical period for renal nerve involvement.
The borderline hypertensive rat (BHR) shows large blood pressure responses to either stress or a high salt diet. Since the renal nerves have been shown to play a role in several animal models of hypertension, the current study sought to determine the effect of bilateral renal denervation on the development of stress-induced hypertension in the BHR. BHR were deprived of renal nerves under ether anesthesia after either 5 or 11 weeks of daily 2-hour stress sessions. Additional BHR received sham surgery. Unstressed BHR, age-matched to stressed groups, received denervation or sham surgery. Following a 3 week recovery period, the protocol (stress or no stress) was continued for 10 additional weeks. Tail cuff systolic blood pressures were obtained weekly. BHR stressed for 5 weeks prior to denervation failed to develop hypertension in response to continued stress. Although BHR stressed for 11 weeks prior to denervation showed a temporary reduction in pressure following denervation, blood pressure returned to the hypertensive levels of sham-operated controls after several weeks. Thus, there may be a critical period during which the renal nerves are necessary for the expression of stress-induced hypertension in the BHR. These observations are discussed in relation to the effects of renal denervation on hypertension in various animal models.
Lawler et al. (Sun,) conducted a other in Stress-induced hypertension. Bilateral renal denervation vs. Sham surgery was evaluated on Development of stress-induced hypertension (systolic blood pressure). Bilateral renal denervation prevented the development of stress-induced hypertension in borderline hypertensive rats when performed after 5 weeks of stress, but not after 11 weeks.