Early repolarization syndrome is associated with a considerable risk of life-threatening arrhythmias and sudden cardiac death, with a prevalence varying between 3% and 24%.
This review highlights that early repolarization syndrome is not always benign and can be associated with sudden cardiac death, emphasizing the need for better risk stratification in asymptomatic patients.
Early repolarization syndrome (ERS), demonstrated as J-point elevation on an electrocardiograph, was formerly thought to be a benign entity, but the recent studies have demonstrated that it can be linked to a considerable risk of life - threatening arrhythmias and sudden cardiac death (SCD). Early repolarization characteristics associated with SCD include high - amplitude J-point elevation, horizontal and/or downslopping ST segments, and inferior and/or lateral leads location. The prevalence of ERS varies between 3% and 24%, depending on age, sex and J-point elevation (0.05 mV vs 0.1 mV) being the main determinants. ERS patients are sporadic and they are at a higher risk of having recurrent cardiac events. Implantable cardioverter-defibrillator implantation and isoproterenol are the suggested therapies in this set of patients. On the other hand, asymptomatic patients with ERS are common and have a better prognosis. The risk stratification in asymptomatic patients with ERS still remains a grey area. This review provides an outline of the up-to-date evidence associated with ERS and the risk of life - threatening arrhythmias. Further prospective studies are required to elucidate the mechanisms of ventricular arrhythmogenesis in patients with ERS.
Ali et al. (Thu,) conducted a review in Early repolarization syndrome (ERS). Early repolarization syndrome is associated with a considerable risk of life-threatening arrhythmias and sudden cardiac death, with a prevalence varying between 3% and 24%.