What is the direct effect of catecholamines and other vasoactive substances on superficial hand veins in humans?
This physiological study characterizes the distinct venoconstrictor and venodilator properties of various vasoactive substances on human superficial hand veins.
The direct effect of catecholamines and other vasoactive substances on superficial hand veins has been studied in man. Drugs were infused locally into the vein and changes in vein size at a constant congesting-pressure were measured by a simple optical technique. 2. Noradrenaline, adrenaline, 5-hydroxytryptamine and angiotensin II caused venoconstriction. Large doses of angiotensin II resulted in rapid development of tachyphylaxis. 3. Isoprenaline, bradykinin, acetylcholine and histamine had no effect on the relaxed vein but all caused dilatation when infused into veins preconstricted by noradrenaline or 5-hydroxytryptamine. 4. No effect of vasopressin could be demonstrated.
Collier et al. (Fri,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: