Female sex was associated with a significantly higher risk of short-term mortality following isolated CABG compared to male sex (adjusted OR 1.39; 95% CI 1.04 to 1.86; p=0.027).
Cohort (n=13,327)
Does female sex increase the risk of short-term mortality in patients undergoing isolated CABG?
Female sex is an independent risk factor for short-term mortality after isolated CABG, translating to a clinically significant number of excess deaths among women.
Odds Ratio: 1.39 (95% CI 1.04–1.86)
p-value: p=0.027
OBJECTIVE: Female sex is considered a risk factor for adverse outcomes following isolated coronary artery bypass graft (CABG) surgery. We assessed the association between sex and short-term mortality following isolated CABG, and estimated the 'excess' deaths occurring in women. METHODS: Short-term mortality was investigated in 13 327 consecutive isolated CABG patients in North Texas between January 2008 and December 2012. The association between sex and CABG short-term mortality, and the excess deaths among women were assessed via a propensity-adjusted (by Society of Thoracic Surgeons-recognised risk factors) generalised estimating equations model approach. RESULTS: Short-term mortality was significantly higher in women than men (adjusted OR=1.39; 95% CI 1.04 to 1.86; p=0.027). This significantly greater risk translates into 35 'excess' deaths among women included in this study (>10% of the total 343 deaths in the study cohort) and into 392 'excess' deaths among the ∼40 000 women undergoing isolated CABG in the USA each year. CONCLUSIONS: The higher risk associated with female sex lead to 35 'excess' deaths in women in this study cohort (over 10% of the total deaths) and to 392 'excess' deaths among women undergoing isolated CABG in the USA each year. Further research is needed to assess the causal mechanisms underlying this sex-related difference. Results of such work could inform the development and implementation of sex-specific treatment and management strategies to reduce women's mortality following CABG. Based on our results, if such work brought women's short-term mortality into line with men's, total short-term mortality could be reduced by up to 10%.
Filardo et al. (Tue,) conducted a cohort in Isolated coronary artery bypass graft (CABG) surgery (n=13,327). Female sex vs. Male sex was evaluated on Short-term mortality (OR 1.39, 95% CI 1.04 to 1.86, p=0.027). Female sex was associated with a significantly higher risk of short-term mortality following isolated CABG compared to male sex (adjusted OR 1.39; 95% CI 1.04 to 1.86; p=0.027).