Does the SAPIEN 3 transcatheter heart valve improve stent-frame expansion morphology and reduce paravalvular regurgitation compared to the SAPIEN XT?
The flared inflow morphology of the newer-generation SAPIEN 3 valve compared to the SAPIEN XT may explain its association with reduced paravalvular regurgitation post-TAVI.
The newer-generation, balloon-expandable device, the S3, has a flared inflow morphology, whereas the prior-generation device, the S-XT, has relatively constrained inflow morphology post TAVI. This may contribute to a lesser degree of PVR with the S3.
Kazuno et al. (Mon,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: