September 3, 1992
Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction
Key Result
Long-term administration of captopril in patients with left ventricular dysfunction post-myocardial infarction improved survival and reduced major cardiovascular events.
Key Points
- To evaluate the impact of long-term captopril on mortality and morbidity in patients with left ventricular dysfunction post-myocardial infarction.
- Long-term administration of captopril was tested in patients with left ventricular dysfunction.
- Assessment of survival rates and major cardiovascular events.
- Comparison of outcomes in patients receiving captopril with those receiving other therapies like thrombolytic therapy, aspirin, or beta-blockers.
- Captopril administration improved survival in patients with left ventricular dysfunction.
- There was a reduction in morbidity and mortality due to major cardiovascular events observed with captopril treatment.
- Benefits were noted in both patients receiving other therapies and those who did not.
Structured PICO
Does long-term administration of captopril improve survival and reduce cardiovascular morbidity and mortality in patients with asymptomatic left ventricular dysfunction after myocardial infarction?
P
Population
Patients with asymptomatic left ventricular dysfunction after myocardial infarction
I
Intervention
Long-term administration of captopril
O
Outcome
Survival and morbidity and mortality due to major cardiovascular eventshard clinical
Long-term captopril therapy improves survival and reduces major cardiovascular events in patients with asymptomatic left ventricular dysfunction post-myocardial infarction.
Main Result
Absolute Event Rate: 0% vs 0%
Abstract
In patients with asymptomatic left ventricular dysfunction after myocardial infarction, long-term administration of captopril was associated with an improvement in survival and reduced morbidity and mortality due to major cardiovascular events. These benefits were observed in patients who received thrombolytic therapy, aspirin, or beta-blockers, as well as those who did not, suggesting that treatment with captopril leads to additional improvement in outcome among selected survivors of myocardial infarction.
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Authors
Marc A. Pfeffer
Heart Failure & Transplant
Eugene Braunwald
Semmelweis University
L
Lemuel A. Moyé
Boston University
Journals
New England Journal of Medicine
Actions
Institutions
Harvard University
Brigham and Women's Hospital
References and Citations
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