Extreme levels of exercise can paradoxically impair vascular function in otherwise healthy individuals, driven by the causative role of reactive oxygen species.
Does extreme exercise impair vascular function in healthy individuals?
While exercise generally improves vascular homeostasis, extreme levels of exercise may paradoxically impair vascular function in healthy individuals due to reactive oxygen species.
Exercise is a powerful therapy for preventing the onset of and slowing the progression of cardiovascular disease. Increased shear stress during exercise improves vascular homeostasis by both decreasing reactive oxygen species and increasing nitric oxide bioavailability in the endothelium. While these observations are well accepted as they apply to individuals at risk for cardiovascular disease, less is known about how exercise, especially intense exercise, affects vascular function in healthy individuals. This review highlights examples of how vascular function can paradoxically be impaired in otherwise healthy individuals by extreme levels of exercise, with a focus on the causative role that reactive oxygen species play in this impairment.
Durand et al. (Sat,) conducted a review in Healthy individuals. Extreme levels of exercise was evaluated on Vascular function impairment. Extreme levels of exercise can paradoxically impair vascular function in otherwise healthy individuals, driven by the causative role of reactive oxygen species.
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