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A severe hemorrhagic disease, characterized by a prolonged whole blood coagulation time due to the delayed formation of thrombin, has been described. The patient with this disease was found to have normal plasma concentrations of all the previously described coagulation factors. 2. The corrective factor in normal plasma or serum can be removed by barium sulfate adsorption. A method for the partial purification and concentration of the patient's missing factor has been outlined. The defect in the patient's blood may be corrected by the addition of plasma free of previously described thromboplastin components (e.g. platelet-free hemophilic plasma), as well as by small amounts of tissue thromboplastin. The name plasma thromboplastin component (PTC) has been assigned to this previously undescribed coagulation factor.
Aggeler et al. (1952) studied this question.