January 3, 2008Open Access
View Full PaperSmoking and the Risk of Incident Hypertension in Middle-aged and Older Men
Key Result
Current and past cigarette smoking increased the risk of incident hypertension compared with never smoking (RR 1.15 and 1.08, respectively) in middle-aged and older men.
Study Design
Type
Cohort (n=13,529)
Structured PICO
Does cigarette smoking increase the risk of incident hypertension in middle-aged and older men free of baseline hypertension and cardiovascular disease?
P
Population
13,529 middle-aged and older men free of baseline hypertension and cardiovascular disease, followed for a median of 14.5 years.
E
Exposure
Cigarette smoking (categorized as past, current <20 cigarettes/day, or current >=20 cigarettes/day)
C
Comparator
Never smokers
O
Outcome
Incident hypertension (defined as either the initiation of antihypertensive treatment, self-reported systolic blood pressure >=140 mm Hg, or diastolic blood pressure >=90 mm Hg) over a median follow-up of 14.5 yearssurrogate
Cigarette smoking is associated with a modest but important increased risk of developing incident hypertension in middle-aged and older men.
Main Result
Relative Risk: 1.15
Abstract
BACKGROUND: Cigarette smoking is a known risk factor for cardiovascular disease (CVD), but its relationship to the development of hypertension is unclear. Previous epidemiological studies have shown inconsistent results, having demonstrated inverse and positive associations between cigarette smoking and the development of hypertension. METHODS: We analyzed 13,529 male participants from the Physicians' Health Study free of baseline hypertension and CVD who provided information about smoking status. Smoking status was categorized as never, past, or current or =20 cigarettes/day. Incident hypertension was defined as either the initiation of antihypertensive treatment, self-reported systolic blood pressure (BP) > or =140 mm Hg, or diastolic BP > or =90 mm Hg. RESULTS: Over a median follow-up of 14.5 years, 4,904 men developed hypertension. We modeled the risk of developing hypertension by baseline smoking status adjusting for known risk factors for hypertension or CVD. In a fully adjusted Cox proportional hazards model, we found that compared with never smokers, past smokers and current smokers had corresponding relative risks (RRs) of 1.08 and 1.15 of developing hypertension. The risk for smokers did not appear to differ based on number of cigarettes smoked daily. Further, the RR of hypertension was higher for men with normal vs. prehypertensive levels of systolic (SBP) or diastolic BP (DBP). CONCLUSIONS: This prospective cohort data suggests that cigarette smoking may be a modest but important risk factor for the development of hypertension.