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Promising promiscuity: Guest editors Maria Laura Bolognesi and Andrea Cavalli set the stage for this ChemMedChem Special Issue on Polypharmacology and Multitarget Drugs. They highlight cases in which a departure from the "one target, one drug" paradigm has proven advantageous, with single molecules that can engage two or more targets to address a given pathology. Articles in this issue underscore the importance of focusing ever more attention to polypharmacology in drug discovery efforts.
Bolognesi et al. (Sat,) studied this question.
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