Acute administration of DPI 201-106 prolonged the QT interval and provoked ventricular tachyarrhythmias in 3 patients, mimicking long QT syndrome type 3.
Case Report (n=3)
Does acute administration of DPI 201-106 provoke long QT syndrome and ventricular tachyarrhythmias?
Delaying sodium channel inactivation with DPI 201-106 causes an acquired form of long QT syndrome mimicking LQT3, leading to dangerous ventricular arrhythmias.
DPI 201-106 delays sodium channel inactivation. Acute administration of DPI 201-106 prolonged the QT interval, provoked spontaneous torsades de pointes in one patient, and facilitated stimulation-induced polymorphic ventricular tachyarrhythmias in two patients. Similar to the observations in animal studies, delaying sodium channel inactivation is a new form of the acquired long QT syndrome, mimicking long QT syndrome type 3.
Kühlkamp et al. (Thu,) conducted a case report in Acquired long QT syndrome (n=3). DPI 201-106 was evaluated on QT interval prolongation and ventricular tachyarrhythmias. Acute administration of DPI 201-106 prolonged the QT interval and provoked ventricular tachyarrhythmias in 3 patients, mimicking long QT syndrome type 3.