Antigenic Properties of Other Experimental Tumors

The field dealing with the specific antigenicity of experimental tumors, growing in genetically compatible hosts, i.e., animals containing all isoantigens of the primary, autochthonous host, is still in the stage of fact collection and critical evaluation. It would seem premature to attempt an assessment of the broader significance of the findings hitherto obtained, still limited to only a few host tumor systems and essentially to one species, the mouse. While general conclusions and detailed theoretical schemes appear to be unwarranted by the experimental facts available at the present time, it seems quite clear that in certain isologous host tumor systems in the mouse it is possible to demonstrate a fairly strong tumor-specific antigenicity. Other systems are characterized by a weaker antigenicity and the same techniques that are suitable for the demonstration of such antigenicity do not show the presence of tumor-specific antigens in still other systems. Obviously, negative findings...