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Under pathologic conditions, significant parallel variation was found between levels of plasminogen and fibrinogen. Both plasminogen and fibrinogen act as acute-phase reactants, increasing with such conditions as infection, trauma, surgery, myocardial infarction, and maligant disease. Levels of both are reduced in patients with advanced cirrhosis of the liver and diffuse intravascular coagulation. The plasminogen level is normal in patients with congenital hypofibrinogenemia or afibrinogenemia. Oral contraceptives increase the level of plasminogen but not that of fibrinogen.
Lackner et al. (Wed,) studied this question.