Does vessel dilator improve renal function and mortality in a rat model of established acute renal failure?
Vessel dilator significantly improves renal function, reverses left ventricular dilation, and reduces mortality in a rat model of established acute renal failure.
Seventeen Sprague-Dawley rats had ischemic nonoliguric acute renal failure (ARF) induced by vascular clamping resulting in their preischemic blood urea nitrogen (BUN) and creatinine levels of 16 +/- 1 and 0.56 +/- 0.05 mg/dl to increase to 162 +/- 4 and 8.17 +/- 0.5 mg/dl, P 75% in the placebo-treated ARF animals. We conclude that vessel dilator improves acute tubular necrosis and renal function in established ARF.
Clark et al. (Mon,) studied this question.