Each 1 SD increment of log-transformed high-sensitivity cardiac troponin I was associated with an increased hazard of incident coronary heart disease (HR 1.11; 95% CI 1.01-1.23; p=0.04).
Cohort (n=1,135)
Yes
Does high-sensitivity cardiac troponin I (hs-cTnI) measurement predict incident coronary heart disease in asymptomatic older adults?
High-sensitivity cardiac troponin I provides incremental prognostic value for predicting incident coronary heart disease in asymptomatic older adults beyond traditional risk factors.
Hazard Ratio: 1.11 (95% CI 1.01–1.23)
p-value: p=0.04
OBJECTIVE: High-sensitivity cardiac troponin I (hs-cTnI) is a novel biomarker of myocardial injury and ischaemia. Our objective was to ascertain correlates of hs-cTnI and its incremental prognostic utility for incident coronary heart disease (CHD) among older asymptomatic subjects. METHODS: We performed a cohort study among 1135 asymptomatic control participants in the ADVANCE (Atherosclerotic Disease, VAscular FunctioN and GenetiC Epidemiology) study at Kaiser Permanente Northern California and Stanford University, with follow-up through 31 December 2014. Hs-cTnI was measured in stored baseline (2002-2004) serum samples. RESULTS: After a median follow-up of 11.3 years, 164 CHD events were documented. The most significant correlates of hs-cTnI were black race, body mass index, hypertension, LDL cholesterol and estimated glomerular filtration rate (eGFR) (R(2)=0.16) After adjustment for race/ethnicity, education level, diabetes status, ATP-III Framingham risk score (FRS), C reactive protein and eGFR, each 1 SD increment of log-transformed Hs-cTnI was associated with 1.11 (95% CI 1.01 to 1.23, p=0.04) increased hazard of CHD. The c-statistic increased to 0.70 from 0.68 (p=0.16) and the category-based net reclassification index was 18% (95% CI 8% to 30%) after adding hs-cTnI to the model containing the ATP-III FRS. CONCLUSIONS: Hs-cTnI conveys incremental prognostic information for incident CHD among asymptomatic older adults.
Iribarren et al. (Wed,) conducted a cohort in incident coronary heart disease (n=1,135). High-sensitivity cardiac troponin I (hs-cTnI) was evaluated on incident coronary heart disease (CHD) (HR 1.11, 95% CI 1.01 to 1.23, p=0.04). Each 1 SD increment of log-transformed high-sensitivity cardiac troponin I was associated with an increased hazard of incident coronary heart disease (HR 1.11; 95% CI 1.01-1.23; p=0.04).
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