T2 mapping at 7T MRI accurately quantified intramyocardial hemorrhage volume compared to pathological gross measurements (4.8% vs. 5.3%; P=0.11) with 93% sensitivity and 90% specificity.
Does T2 mapping at 7T MRI accurately detect and quantify intramyocardial hemorrhage in female rats with induced myocardial infarction?
T2 mapping at 7T MRI provides a reliable, noninvasive quantitative approach to assess intramyocardial hemorrhage in a preclinical model of reperfused myocardial infarction.
Tasa de eventos absoluta: 4.8% vs 5.3%
valor p: p=0.11
PURPOSE: To investigate T2 mapping at 7T magnetic resonance imaging (MRI) for the detection and quantification of reperfused intramyocardial hemorrhage (IMH) in a rat model. MATERIALS AND METHODS: Myocardial infarction (MI) was induced in 25 female rats. Rats were scanned at a 7T MRI 48 hours after reperfusion, using T2 mapping and late gadolinium enhancement imaging. Gross sections of the left ventricular myocardium and corresponding hematoxylin and eosin staining were assessed for IMH. T2 mapping images were matched with the gross sections. The IMH volume, expressed as a percentage of the left ventricular myocardial volume, of each heart determined by T2 mapping was compared with that calculated by pathological gross examination. RESULTS: Six rats died. In all, 97 gross sections of the left ventricular myocardium from the 19 rats were matched with T2 mapping images. IMH occurred pathologically in 68 gross sections, which was detected as hypointense cores by T2 mapping in 63 images (93% sensitivity). Three T2 mapping images with hypointense cores showed no hemorrhage on pathological sections (90% specificity). The positive and negative predictive values of hemorrhage on T2 mapping were 95% and 84%, respectively. In terms of the IMH volume, there was no significant difference between T2 mapping and pathological gross measurements (4.8 ± 2.4% vs. 5.3 ± 3.2%; P = 0.11). CONCLUSION: T2 mapping at 7T MRI can reliably detect and quantify IMH in rats in vivo. This may be useful as a noninvasive quantitative approach to investigating the mechanisms and evolution of MI and reperfusion injury. J. Magn. Reson. Imaging 2016;44:194-203.
Chen et al. (Wed,) conducted a other in Acute reperfused myocardial infarction (n=25). T2 mapping at 7T MRI vs. Pathological gross examination was evaluated on Intramyocardial hemorrhage (IMH) volume (p=0.11). T2 mapping at 7T MRI accurately quantified intramyocardial hemorrhage volume compared to pathological gross measurements (4.8% vs. 5.3%; P=0.11) with 93% sensitivity and 90% specificity.