Key points are not available for this paper at this time.
Zucker obese rats are normoglycemic, hyperinsulinemic, and release more insulin from isolated pancreatic islets than do their nonobese controls. Basal glucose conversion to glycogen by muscle and to CO2 by isolated adipocytes is similar in Zucker obese and nonobese; insulin resistance is present in both tissues in the obese. There is a significant correlation between adipocyte response to insulin and pancreatic insulin release in obese and nonobese rats. The authors suggest a role for adipocytes in determining pancreatic function.
Stern et al. (Sat,) studied this question.