The mean Valsalva ratio was significantly reduced in hypertensive diabetic subjects (1.1883) compared to healthy controls (1.3137), indicating enhanced autonomic dysfunction due to co-morbidity.
Cross-Sectional (n=90)
No
Does the coexistence of hypertension and Type II diabetes mellitus worsen autonomic dysfunction as measured by heart rate variability during the Valsalva maneuver compared to healthy controls?
The coexistence of hypertension and Type II diabetes mellitus is associated with significantly greater autonomic dysfunction, as evidenced by a reduced Valsalva ratio, compared to healthy individuals or those with hypertension alone.
Absolute Event Rate: 1.1883% vs 1.3137%
p-value: p=highly significant
Background-Hypertension and Diabetes are known to have autonomic dysfunction and indices of heart rate variability provide window to understand the autonomic modulation of cardio respiratory systems. Hypothesis-Co existing morbidity in Hypertensive diabetic group will cause enhancement of autonomic dysfunction. Design-Hospital based case-control study. Hypertensive and Hypertensive diabetics (30 males each), not on regular medicines were selected from the Medicine and Diabetic OPD over a period of one year,and included in the study. Age and sex matched healthy controls were selected from hospital staff.Heart rate variability tests were done in the research laboratory of department of Physiology. Materials and methods-After proforma the basal heart rate and resting blood pressures were recorded for each subject. Valsalva maneuver and the ECG recording was done on Polyrite-D Machine for one minute. Valsalva ratio was calculated. Statistical analysis-ANOVA, Tuckeys, and Pearson co-relation coefficient tests were used to analyze the appropriate data. Results-The mean VR of hypertensive subjects was.1.2647 + 0.1608,statistically not significant when compared to healthy (1.3137 + 0.1714).The mean VR of hypertensive diabetics was 1.1883+ 0.1302,statistically highly significant.
Lata Patil (Tue,) conducted a cross-sectional in Hypertension and Type 2 Diabetes Mellitus (n=90). Hypertension and Type 2 Diabetes Mellitus vs. Healthy controls was evaluated on Valsalva ratio (VR) (p=highly significant). The mean Valsalva ratio was significantly reduced in hypertensive diabetic subjects (1.1883) compared to healthy controls (1.3137), indicating enhanced autonomic dysfunction due to co-morbidity.