Key points are not available for this paper at this time.
The adenovirus-associated viruses (AAV) are a newly recognized group of defective viruses that are capable of multiplying only in cell cultures infected with an adenovirus. Their natural history is unknown, since they have been identified only as contaminants of laboratory stocks of adenoviruses. This report describes the detection of antibodies to AAV serotypes 1, 2, and 3 in human sera by neutralization, complement fixation, and immunofluorescence tests. The curve of antibody frequency showed a steep rise between the ages of 1 and 10; about one-half of older children and adults showed antibodies to one or more AAV serotypes. AAV seroconversions were demonstrated by neutralizing and/or CF antibody in 5 of 12 children residing in a receiving home for young children in 1957–58 and in 7 of 28 children residing there in 1965–66. These findings therefore strongly indicate that man is naturally infected with viruses of the AAV group. Captive African green monkeys frequently showed antibody to AAV 4. Antibodies to all 4 AAV serotypes were found in a low proportion of captive but not in wild rhesus monkeys.
Blacklow et al. (1968) studied this question.