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The immunoperoxidase technic was applied to 15 skin lesions of Kaposi's sarcoma to localize factor VIII-related antigen. Factor VIII-related antigen serves as a tissue-specific marker for endothelial cells. Positive staining was observed in all cases. These findings support the endothelial origin of the lesion of Kaposi's sarcoma.
Guarda et al. (1981) studied this question.