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The Risk of Cancer Associated with Specific Mutations ofBRCA1andBRCA2among Ashkenazi Jews | Synapse

May 15, 1997Open Access

The Risk of Cancer Associated with Specific Mutations ofBRCA1andBRCA2among Ashkenazi Jews

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Resumen

Over 2 percent of Ashkenazi Jews carry mutations in BRCA1 or BRCA2 that confer increased risks of breast, ovarian, and prostate cancer. The risks of breast cancer may be overestimated, but they fall well below previous estimates based on subjects from high-risk families.

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Cite This Study

Struewing et al. (Thu,) studied this question.

synapsesocial.com/papers/6924ddfec80e0609b6857681 https://doi.org/https://doi.org/10.1056/nejm199705153362001

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families1996 · 319 citations
2The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1%1996 · 385 citations
3Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA21996 · 777 citations
4LINKAGE MAPPING OF TYPE-1 DIABETES1995 · 90 citations
5Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.1993 · 1,254 citations