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The activation of Factor XII (Hageman Factor) by bovine collagen has been studied in vitro and in vivo. Alkaline eluates obtained from collagen exposed to human and rabbit plasma contained Factors XII and XI, and were found to shorten markedly the whole blood clotting time of rabbits in vivo and in vitro. Formation of stasis thrombi could also be demonstrated in rabbits following injection of collagen eluates. The possible significance of collagen-induced Factor XII activation in the mechanism of hemostasis and thrombosis is discussed.
Niewiarowski et al. (1966) studied this question.