Among elderly individuals aged 65 and older, a systolic blood pressure below 100 mm Hg was associated with a significantly increased risk of vascular mortality compared to 100-119 mm Hg (aHR 2.14).
Cohort (n=6,294)
No
Does low systolic blood pressure increase mortality from all-cause and vascular diseases among the rural elderly in Korea?
In elderly individuals aged 65 and older, a systolic blood pressure <100 mm Hg is associated with increased vascular mortality, indicating a J-curve relationship between SBP and mortality.
Effect estimate: aHR 2.14 (95% CI 1.18-3.88)
p-value: p=0.013
The association between low systolic blood pressure (SBP) and vascular diseases is unclear. The aim of this study was to prospectively examine the association between SBP, especially low SBP, and mortality from all causes and vascular diseases among the elderly in Korea. Six thousand two hundred ninety four residents in a rural community were followed-up for deaths from 1985 to 2008. The adjusted hazard ratios (aHR) and 95% confidence intervals were calculated by Cox proportional hazard model. A stratified analysis was conducted by age at enrollment. Among the elderly aged 65 and above, the lowest SBP (<100 mm Hg) group had an elevated aHR for mortality from vascular diseases (aHR = 2.1, 95% CI = 1.2-3.9) including stroke (aHR = 2.4, 95% CI = 0.9-6.3) and ischemic heart diseases (aHR = 5.1, 95% CI = 1.0-26.0) compared to those with SBP of 100-119 mm Hg, while higher SBP was associated with higher mortality. This J-curve association was generally maintained when analysis was restricted to those with fair or good self-rated health, or those with no known vascular diseases. In people below 65, increasing SBP nearly monotonically increased the mortality from all-cause and vascular diseases. Our results suggest that elderly persons with low SBP should be treated with caution, since low SBP may increase vascular mortality.
Yi et al. (Thu,) conducted a cohort in General rural elderly population (n=6,294). Systolic blood pressure <100 mm Hg vs. Systolic blood pressure 100-119 mm Hg was evaluated on Mortality from vascular diseases (in participants aged ≥65 years) (aHR 2.14, 95% CI 1.18-3.88, p=0.013). Among elderly individuals aged 65 and older, a systolic blood pressure below 100 mm Hg was associated with a significantly increased risk of vascular mortality compared to 100-119 mm Hg (aHR 2.14).