Anaphylactic Reaction Following Injection of Heparin

THE occurrence of reactions following the use of anticoagulants in the management of patients with myocardial infarction, pulmonary infarction and thrombophlebitis and after vascular surgery has served to emphasize the potential danger of these drugs. In general, the reactions either have been local (pain, abscess formation, hematoma, necrosis) or have resulted from overdosage, with bleeding into various parts of the body. Little has been written concerning allergic reactions to anticoagulants, particularly to heparin. Thus, Murray1 reported on the use of heparin in 440 patients without the occurrence of anaphylaxis. Crafoord and Jorpes2 analyzed the results of some 30,000 doses of . . .