Key points are not available for this paper at this time.
The overall effectiveness of all of the five models could be ranked in decreasing order as follows: Atom pair Formula: see text Topological > Morgan > MACCS > Pharmacophore. Combining multiple SEA models, which takes advantages of different models, could be used to improve the success rates of the models. Another possibility of improving the model could be using target-specific classes or more active compounds.
Wang et al. (Sat,) studied this question.