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Abstract Serum concentrations of estradiol-17β (E2), gonadotropins and long acting thyroid stimulator were studied in 10 consecutive male patients with active Graves's disease. Serum E2 was elevated in all patients before therapy. In two men with gynecomastia the concentrations were as high as those observed in normal women. The per cent dialyzable E2 was significantly reduced in hyperthyroid males as compared to normal males and was similar to that seen in eugonadal women; but the absolute concentration of unbound E2, evaluated in one prepubertal and five adult patients without gynecomastia, was elevated in four of the five adults. The mean serum concentrations of luteinizing and follicle-stimulating hormones were also higher in the hyperthyroid men than in normal men. Serum E2 fell gradually and consistently during effective treatment of hyperthyroidism with propylthiouracil. Neither the occurrence of gynecomastia nor the serum concentration of E2 correlated with serum concentration of long acting thyro...
CHOPRA et al. (Thu,) studied this question.