Does nadroparin reduce atrial fibrosis and the complexity of the atrial fibrillation substrate in animal models of persistent AF?
Inhibition of coagulation with nadroparin attenuates atrial fibrosis and AF substrate complexity in animal models, suggesting anticoagulation may have disease-modifying effects in AF beyond stroke prevention.
The hypercoagulable state during AF causes pro-fibrotic and pro-inflammatory responses in adult atrial fibroblasts. Hypercoagulability promotes the development of a substrate for AF in transgenic mice and in goats with persistent AF. In AF goats, nadroparin attenuates atrial fibrosis and the complexity of the AF substrate. Inhibition of coagulation may not only prevent strokes but also inhibit the development of a substrate for AF.
Spronk et al. (Tue,) studied this question.
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