Individual differences in the intensity of the post-AMI inflammatory response may contribute to adverse left ventricular remodeling, offering potential novel therapeutic targets.
Does the intensity of the post-AMI inflammatory response contribute to adverse left ventricular remodeling?
Individual variations in the inflammatory response post-AMI may contribute to adverse LV remodeling and represent novel therapeutic targets.
Treatment of acute myocardial infarction (AMI) has improved significantly in recent years, but many patients have adverse left ventricular (LV) remodeling, a maladaptive change associated with progressive heart failure. Although this change is usually associated with large infarcts, some patients with relatively small infarcts have adverse remodeling, whereas other patients with larger infarcts (who survive the first several days after AMI) do not. This paper reviews the relevant data supporting the hypothesis that individual differences in the intensity of the post-AMI inflammatory response, involving 1 or more inflammatory-modulating pathways, may contribute to adverse LV remodeling. It concludes by outlining how individual variations in the inflammatory response could provide important novel therapeutic targets and strategies.
Westman et al. (Sat,) conducted a review in Acute Myocardial Infarction (AMI) and adverse left ventricular remodeling. Individual differences in the intensity of the post-AMI inflammatory response may contribute to adverse left ventricular remodeling, offering potential novel therapeutic targets.