FD-OCT-based 3D coronary reconstruction highly correlated with IVUS for lumen area (r=0.96) and local ESS (r=0.89), yielding 94.9% diagnostic accuracy for detecting proatherogenic low ESS.
Observational (n=15)
Does FD-OCT-based 3D coronary reconstruction provide accurate endothelial shear stress assessment compared to IVUS-based models in patients undergoing coronary angiography?
FD-OCT-based 3D coronary reconstruction provides anatomically correct models and permits reliable endothelial shear stress computation comparable to established IVUS-based models.
Effect estimate: AUC 94.9%
AIMS: To develop a methodology that permits accurate 3-dimensional (3D) reconstruction from FD-OCT and angiographic data enabling reliable evaluation of the ESS distribution, and to compare the FD-OCT-derived models against the established models based on angiography/IVUS. METHODS AND RESULTS: Fifteen patients (17 coronary arteries) who underwent angiography, FD-OCT and IVUS examination during the same procedure were studied. The FD-OCT and IVUS lumen borders were placed onto the 3D luminal centreline derived from angiographic data. Three-dimensional geometry algorithms and anatomical landmarks were used to estimate the orientation of the borders appropriately. ESS was calculated using computational fluid dynamics. In 188 corresponding consecutive 3-mm segments, FD-OCT- and IVUS-derived models were highly correlated for lumen area (r=0.96) and local ESS (r=0.89) measurements. FD-OCT-based 3D reconstructions had a high diagnostic accuracy for detecting regions exposed to proatherogenic low ESS identified on the IVUS-based 3D models, considered as the gold standard (receiver operator characteristic area under the curve: 94.9%). CONCLUSIONS: FD-OCT-based 3D coronary reconstruction provides anatomically correct models and permits reliable ESS computation. ESS assessment in combination with the superior definition of plaque characteristics by FD-OCT is expected to provide valuable insights into the effect of the haemodynamic environment on the development and destabilisation of high-risk plaques.
Papafaklis et al. (Sat,) conducted a observational in Coronary artery disease (n=15). FD-OCT-based 3D coronary reconstruction vs. IVUS-based 3D models was evaluated on Correlation of lumen area and local endothelial shear stress (ESS), and diagnostic accuracy for detecting proatherogenic low ESS (AUC 94.9%). FD-OCT-based 3D coronary reconstruction highly correlated with IVUS for lumen area (r=0.96) and local ESS (r=0.89), yielding 94.9% diagnostic accuracy for detecting proatherogenic low ESS.