May 5, 2016Open Access

Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase

DDDres DamgaardNovo Nordisk (Denmark)MBMads Emil BjørnRigshospitalet MSMaria Abildgaard SteffensenUniversity of Copenhagen

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Abstract

Catalytic activity of PAD requires reducing conditions. GSH meets this requirement at concentrations comparable with those found within cells. Active PAD, reduced by GSH, is released from PMA-stimulated granulocytes, but becomes inactivated in the extracellular space.

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Damgaard et al. (Thu,) studied this question.

synapsesocial.com/papers/69d8efa21ab91f1400bed999 https://doi.org/https://doi.org/10.1186/s13075-016-1000-7

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